The History and Benefits of CBD Through Time- the evolution of cannabis as a medical remedy
Although CBD may seem like a modern remedy, its history stretches back a very long way. In fact, Cannabis Sativa L. has been used for years to help treat a wide variety of ailments. Some of the evidence even suggests that cannabis was one of the first plants that human beings cultivated. Across the world, and in very different cultures, there are accounts of people making medicinal use of cannabis.
The archaeological records suggest that cannabis cultivation dates back to the end of the first Ice Age and the beginnings of agriculture around 10,000 to 12,000 years ago. Its initial use was probably for textiles, but its first documented medicinal use was in 2737 BC when the Chinese Emperor, Sheng Nung, drank Cannabis-infused tea. Sheng Nung is sometimes known as the ‘Father Of Chinese Medicine’ and is believed to be the author of The Pen T’Sao or The Great Herbal, which contains a wide range of natural remedies. It includes cannabis, which is said to relieve menstrual pain, rheumatism, gout, and malaria, among other ailments. By the 2nd century AD, cannabis was being used in China as a medical anesthetic and a treatment for blood clots and tapeworm. But it wasn’t just China that was using medicinal cannabis in the ancient world; records from Egypt and Greece indicate they were using it too, sometimes to treat wounds or added to baths as a relaxant.
In the Medieval Islamic Era, Arab physicians were making extensive use of cannabis for all kinds of reasons. It was used as an antiseptic and an analgesic, as well as a treatment for epilepsy and fevers, right up until the 18th century. In the Western World, the introduction of medicinal cannabis is credited to William Brooke O’Shaughnessy, an Irish physician, and medical researcher. In 1839, he published a groundbreaking study investigating the plant’s therapeutic effects. In his wide-ranging work, he explored the use of cannabis as an anesthetic among other potential medical applications. At a similar time in France, the well-traveled psychiatrist Jacques-Joseph Moreau experimented with using cannabis to treat melancholia and migraines. Cannabis grew in popularity as a sedative and pain relief, with Queen Victoria believed to have used it to relieve crippling period pain. As syringes were developed to administer pain relief much more quickly, interest in cannabis as a medicinal treatment fell out of favor for a while. But the 20th century would see it return.
The re-emergence of CBD and cannabinoids as medical remedies
Around a century after William Brooke O’Shaughnessy’s groundbreaking work, the development of advanced research and technology techniques made a wholesale study of cannabis and its compounds possible. In 1940, the British chemist Robert S.Cahn identified the structure of a cannabinoid, which we today refer to as Cannabinol or CBD. Two years later, the American chemist, Robert Adams, successfully isolated the very first cannabinoid. Although rudimentary by 21st century standards, this pioneering work has made CBD as we understand it today possible.
This early research had its limitations. Scientists only had limited knowledge of the cannabinoid structure. Their understanding of CBD plant’s biological composition was restricted, and as a result, they couldn’t confidently predict which compound was causing a particular effect.
A breakthrough came in 1963 when Dr. Raphael Mechoulam successfully identified the stereochemistry of CBD. A year later, Mechoulam identified the stereochemistry of tetrahydrocannabinol, or THC, which is the component in marijuana that causes the user to become ‘high’ or euphoric. Having isolated the intoxicating element successfully, CBD was disassociated from this aspect of cannabis use. This finding would have implications for its use as a medicinal substance. In the 1980s, Dr. Mechoulam and his research team conducted a study into CBD use as a treatment for epilepsy, echoing records of Islamic scholars from centuries past. The study discovered that after four months of a daily dose of CBD, half of the participants completely stopped experiencing seizures.
Mechoulam and his team continued their work throughout the ’80s and into the ’90s. In 1988, the first cannabinoid receptor was found in the brain of a rat. In 1993, a second cannabinoid receptor was discovered, located throughout the immune system and peripheral tissues. As research continued, these receptors were found to exist in the brains of many different animals, including humans, and they interacted exclusively with compounds found in cannabis. While this didn’t prove that cannabinoids could have any positive medical impact on our health and well-being, it appeared that our body’s design interacts with cannabinoids.
Since the late ’90s, research has been ongoing into the endocannabinoid system with startling results. Although much remains unknown, today, we have a fuller picture of how CBD interacts with and affects our bodies. During the 1990s, a series of legislative changes began in the United States and made medical research into CBD increasingly possible. In the US, California passed Proposition 215, also known as the Compassionate Use Act, in 1996, making it the first state to legalize the medical use of marijuana. Seven other states soon followed. In those states, patients with various conditions could now use medical marijuana, and it allowed for researchers to expand the range of their research. While scientists increasingly came to understand the positive role CBD could play in treating various conditions, the public and policymakers lagged. That slowly began to change as individuals who had benefited from CBD started to tell their stories.
One of the most striking of these is the story of Charlotte Figi, who was born in Colorada in 2006 with a very rare and debilitating type of epilepsy called Dravet Syndrome. By the age of four, Charlotte experienced approximately 300 seizures a week and had lost the ability to talk, walk, and eat. After trying everything that modern medicine could come up with but to little effect, her parents hesitantly tried CBD oil. The results were incredible, with Charlotte now only experiencing 2 or 3 seizures a month and most of her normal functions returning. This astonishing case prompted further research into the benefits of CBD therapies. In the UK, a cannabis-based medicine, Epidolex, is now issued by the NHS for the treatment of severe epilepsy conditions that are otherwise difficult to treat.
The body of research into CBD oil’s medical benefits continues to grow as more people experience the benefits of CBD for themselves. Interest in CBD as a treatment for epilepsy continues, alongside its potential to treat other neuropsychiatric disorders. Research lags behind CBD oil users’ experience, and with every year that passes, sales of CBD products grow around the world. A comprehensive body of research by the World Health Organisation in 2018 found no public health risks associated with CBD oil. Instead, CBD offers many potential medical benefits and applications. It’s been a long, convoluted history. CBD oil is finally achieving mainstream recognition as a treatment for a growing range of health conditions (5% CBD and 10% CBD Oils are the most widely used forms of CBD Oil)
What are the benefits of CBD products?
1. CBD Benefits for ALS (Amyotrophic Lateral Sclerosis)
Amyotrophic lateral sclerosis, or ALS, is a degenerative condition that gradually destroys the nerves responsible for controlling muscles. An example of a person with severe ALS was Stephen Hawking. ALS can affect people’s ability to communicate, walk, breathe properly, and move. The disease is progressive, similar to other neuron and muscle connected diseases like MS, which means that sufferers’ symptoms can gradually or quickly worsen, depending on many factors. Treatment to give the patient a good quality of life and keep them moving for as long as possible is imperative. There is no known cure for ALS, so the best thing people with this condition and their carers can do is ease the patient’s suffering.
Death occurs in neuronal cells, and medication available treats this, but these cells’ disintegration can only be held back for so long. Recently, a BMC neural Medical journal study suggests CBD oils and compounds may help improve ALS symptoms and lifestyle in general instead of just holding back symptoms.
Treating people with ALS with CBD was found to increase spasticity or increase muscle tone, meaning patients had better use of their muscles than before trying CBD products. Lack of spasticity indicates that sufferers are less likely to use their muscles, affecting walking, talking, and breathing. Current medications on offer have some effect on spasticity, but there are side effects. While these medications can help with specific ALS issues, there’s a chance they could affect lower motor neuron functions, like movement controlled by the spine…a delicate balance between increasing spasticity and muscle movement and making the condition worse. Therefore, to find a way to increase spasticity is incredible and could lead to life-changing results for patients who suffer from Amyotrophic Lateral Sclerosis.
There are other benefits of using CBD products for ALS sufferers. The study on ALS and spasticity is the only available peer-reviewed study currently available involving ALS and CBD product’s benefits. There is much anecdotal evidence that shouldn’t be discounted. Remember, CBD products are relatively new, and long-term testing takes a while. There have been reports of people finding CBD products helpful for ALS symptoms, which has anti-inflammatory properties, protects neurological cells, helps with spasms, and provides antioxidants that boost the immune system.
As CBD products become more popular, there will be more studies and more testing, so expect further developments in the fight against ALS and other muscular dystrophic diseases.
2. Alzheimer’s Disease and CBD
Alzheimer’s is a brain disease that destroys memories and cognitive ability over a period of time. Depending upon the type of Alzheimer’s, this can range from a few years in early-onset cases to over a decade or two in the elderly. It can start by forgetting basic things like house keys or turning off electronics or gas, and progress to a complete loss of memory. There is no known cure for Alzheimer’s, although there are some treatments. Some medications can ease symptoms and slow down progression, but once Alzheimer’s is diagnosed, there is no way of reversing it, unfortunately.
CBD products are now recognized as helpful in the treatment of symptoms of people with Alzheimer’s disease. Some report CBD helps with inflammation in the brain, which exacerbates dementia and worsens symptoms, making the disease progress faster. As an antioxidant, CBD helps the Alzheimer’s-affected brain deal with oxygen-processing problems, getting vital oxygen to the brain, which in turn helps to slow symptoms of dementia.
There have not been many studies done on patients with Alzheimer’s disease to show CBD products and oils’ efficacy. There was, however, a study done by eastern Virginia Medical School that shows that CBD products have a positive effect on agitation in patients with Alzheimer’s. This study concluded that agitation in patients was lessened to different degrees, depending upon the seriousness and the length of the Alzheimer’s the patient was suffering from. Other positive reports from this piece of research were that CBD products had anti-inflammatory and antioxidant effects, helping to keep dementia at bay and attempting to slow down the disease’s progression.
3. The benefits of CBD products for Antibiotic-resistant Bacterial Infections
In recent years, many antibiotics are over-prescribed, and human beings are now becoming immune to more bacterial diseases than ever before. Scientists are increasingly trying to create more and more sophisticated antibiotics in the hopes of defeating horrific bacterial diseases.
Now there is research into boosting the effectiveness of antibiotics instead of making new ones. A compound that is being trialed is CBD. A team from the University of Southern Denmark published a study in March 2020 to prove that at least some antibiotics have increased positive effects when combined with a CBD product. In this study, an experiment was conducted, which showed that with CBD, the bacterial particles could not divide in the usual fashion. Certain gene levels were lowered, meaning cell division and autolysis are less likely, leading to the bacterial membrane becoming unstable…it is easier to destroy the bacteria. In effect, the study reveals that CBD works on its own as a great product to treat many illnesses. It can also work with other medications such as antibiotics to produce more significant effects than just the other medicine
The findings of the study could mean incredible things and bad news for those near impossible to treat superbugs. CBD supercharges antibiotics so that it could be a significant weapon in the fight against new bacterial infections. In the article, there is mention of CBD treating infections on its own, without being combined with an antibiotic, and being effective. Of course, there has to be further testing done to see what CBD products and oils can do when applied to antibiotic-resistant bacterial infections. Still, there is plenty of information, both anecdotal and peer-reviewed out there, which suggests great promise for the product in the future. Expect to see more tests in the next few years, especially as the world moves towards veganism, natural farming, and using natural products like hemp-derived CBD to treat ailments, both major and minor. CBD has many more uses, and you may soon see it in a fight against future superbugs.
4. CBD Benefits for Asthma
Asthma is a disease in which your airways swell, narrow, produce extra mucus, and make it harder to breathe. Any people with asthma will know the feeling of panic as their breath shortens, and they frantically search for their inhaler. Like many other conditions, people with asthma are on a scale of manageable and mild to severe enough that one bad attack could kill them. There is no cure for asthma at the moment, but generally, it can be controlled through inhalers. Asthma can get worse over time, so it’s imperative you keep your asthma appointments with your clinic team up to to date and don’t miss any.
There have been some professional studies performed on the effects of CBD on Asthma. One study, published in Eur J Pharmacol journal, says that CBD acts on specific receptors located in the immune cells and nervous system. These receptors help bolster the immune system to stop asthma symptoms from worsening. Research into CBD products and asthma is in the early stages, so it’s important not to stop seeing your doctor or completely abandon your inhaler. You should see CBD products as a possible way of making your illness easier to manage in tandem with your other medications and therapies and as something that should give you additional benefits on top of those from traditional treatments.
There is also the usual anecdotal evidence, which you shouldn’t discount, although always verify anything you take first with a medical professional. There are far too many people claiming that there are benefits to taking CBD oils and other CBD products for their asthma to ignore this. CBD products act as anti-inflammatories. Since asthma sufferers’ main problem is inflammation of the airways leading to a struggle to breathe, a way to prevent inflammation could be an excellent thing if you have asthma. It would be best if you did not throw away your inhaler right away, as CBD is not proven to stop sudden attacks but provide longer-term benefits, so it will not help quickly.
The effects of CBD products on asthma appear to be positive, but as mentioned above, please consult your doctor, especially if your condition is severe. There will undoubtedly be more developments to come with asthma medication and CBD products in the coming years. Watch this space to see if there will be more help with your asthma soon.
5. The benefits of CBD for Autism Spectrum Disorder
Autism spectrum disorders come in a massive range, with symptoms varying from person to person. Some autism spectrum disorders range from so mild that they have few problems functioning in their day-to-day lives. From a few issues to so severe, the patient is incapacitated and will never live on their own or be without help.
Some symptoms of autism spectrum disorders are problems interacting socially, speech development disorders, certain behaviors like repetitiveness or restricting themselves from doing specific things. Of course, autistic people have many positive skills others don’t possess, like recalling lots of information, an effective brain for sorting data, and developing and becoming experts in certain subjects quickly.
These symptoms and downsides do not apply to every autistic person, and generalizations should not be made, but these things are common. If your autism spectrum disorder is negatively affecting your life more than in a positive way, then it may be time to see what treatment is out there. At the moment, there are a variety of therapies and medications on offer for people with autism. Younger children usually are assigned to behavior and speech therapy before given medication, but being medicated is sometimes the best option if the condition is severe enough. Adults may receive a combination of therapy and medication, but it again depends on the condition’s intensity and seriousness.
CBD products are now becoming a popular way to help with Autistic Spectrum Disorder symptoms, and a study by Front Neural into the use of CBD products in people on the autistic spectrum found 14 out of a sample of 15 showed some signs of improvements. Seizures were the symptom found most improved amongst the participants. Concentration and symptoms linked to ADHD were found to have been part of the highest group of symptom improvements, as well as improvement to sleep. Sleep is a common issue amongst people who have autism and similar disorders such as Attention Deficit Disorder (ADD) and other behavioral disorders. A lack of sleep can make anyone unhappy, and it can make people with a disorder such as autism extremely exhausted, upset, and unable to function. CBD products will help patients get to sleep easier and improve their quality of lifestyle.
There are also anecdotal reports that CBD products can calm people with autism. As CBD is naturally derived, there can be fewer side effects than other, more potent medications. However, you should always consult your doctor or autism specialist before stopping any other medication or starting CBD products. If you are autistic or have a child with the disorder, then it is seriously worth looking into CBD, as if you have tried everything else and it hasn’t worked, this may be the solution to at least some of the problems caused by autism.
6. CBD Benefits for Autoimmune disorders
Autoimmune diseases can be very debilitating conditions and can heavily impact the everyday lives of those who suffer from them. Autoimmune diseases occur when your body’s defense system triggers an abnormal inflammatory response. Examples of these diseases include Lupus, Multiple Sclerosis, Chrons, and Scleroderma. The use of CBD in autoimmune disorders links back to the Endocannabinoid system, as explained in a previous point. This system plays a vital role in how your body works, most notably your brain function, central nervous system and immune systems.
CBD can react to these systems in a similar way to endocannabinoids, triggering a body response by reducing inflammation and boosting the immune system. Research conducted by James M. Nicols and Barbara L.F. Kaplan found that “considering all the studies conducted on immune responses and inflammation, the data overwhelmingly demonstrate that CBD is immune suppressive and anti-inflammatory.” Due to these properties, CBD can help the body deal with the overactive immune system caused by the disease and aid with slowing down symptoms.
One of the possible pathogenesis mechanisms in neurological autoimmune diseases is the disturbance of the blood-brain-barrier (BBB) and the blood-spinal cord barrier (BSCS). A possible link is suggested between pathogenesis in conditions such as Multiple Sclerosis, Guillain-Barre syndrome, and Antiphospholipid Syndrome with neurological involvement. CBD works to protect the BBB and the BCSB (to an extent) to reduce BBB leakage and its effects. CBD is also a highly effective anti-inflammatory, and pain from inflammation is one of the main symptoms of an autoimmune disease. By taking CBD, patients benefit from can occur as a result of the disease, such as depression and anxiety. CBD can also slow down T-cell production (the cells responsible for instigating an immune response to viral infections) and suppress the immune system memory. As a result the person is at a reduced risk of suffering from an autoimmune attack in the future. CBD also deals with oxidative stress, which can reduce cell damage from past autoimmune attacks. While CBD can’t cure autoimmune disorders, it is a viable option for decreasing the symptoms and making sufferers’ lives a lot more manageable.
7. CBD Benefits for Concussions, brain, and spinal cord injuries
Concussion, brain, and spinal cord injuries can all cause cell death, disruption of blood vessels, and brain inflammation, which can have catastrophic implications to daily life. It is why many people turn to CBD, which has potent antioxidant features that can reduce many symptoms.
CBD modulates both ecotoxicity and inflammation and is linked to decreasing inflammatory cell activation, activating serotonin receptors (which can increase your cerebral blood flow), and reducing some of the other debilitating side-effects these injuries can present. When you injure the brain, it becomes inflamed, and blood flow decreases. As a result, your brain cells may die, which affects your mental function and capacity. Many studies have looked into the positive impact of CBD on restoring these functions (to an extent) with positive results. In 2017, a team at the Hebrew University in Jerusalem found that rats and mice subjected to traumatic brain injury (TBI) showed significantly better recovery when treated with cannabinoid compounds, possibly opening the way for clinical trials soon.
A study in 2014 on the “Effect of Marijuana Use on Outcomes in Traumatic Brain Injury” looked at the records of all trauma patients admitted to the Harbour-UCLA Intensive Care unit over two years. Those with traumatic brain injury and who were drug tested were selected for the study. The researchers found that a positive THC screen was associated with decreased mortality in adult patients sustaining TBI. A similar study in 2012 saw researchers restrict blood flow and oxygen levels to newborn rats’ brains to replicate a brain injury. Findings showed that dosing with CBD after this led to long-lasting neuroprotection as it reduced inflammation to the brain and reduced both the volume and extent of brain damage.
For the spinal cord, CBD helps with easing chronic pain, sleeplessness, anxiety, and inflammation. It allows patients to take less medication and doesn’t have the same side effects as many pain medications, such as grogginess. The immunomodulatory and neuroinflammatory properties of CBD contribute to anti-spasticity and pain reduction for a spinal injury, and it is easy to digest. While there isn’t a direct way to cure brain and spinal cord injuries, CBD can make the condition more manageable.
8. CBD Benefits for Anorexia
According to the National Eating Disorder Association, around 30 million people suffer from eating disorders such as anorexia. While it can manifest as a very physical problem, anorexia is a mental illness that can be highly debilitating to those suffering from it. Due to this, people are continually looking at new ways to help combat the disease, and CBD has become an increasingly popular choice.
CBD helps with anorexia in a myriad of ways. One of the first reasons it can help is that it can increase your appetite, allowing those who struggle with anorexia to eat and put on weight. CBD working to make you more hungry was found in a study conducted by Scherma et al. for the Current Pharmaceutical Design publication. In the research, it was found that CB1 agonists are orexigenic, which helps to increase appetite and the body’s positive reaction to eating. The CB1 receptor, also known as the cannabinoid receptor, is a G protein-coupled cannabinoid receptor activated by endocannabinoids (CBD). A phase 2 clinical trial of 18 patients with cancer-related anorexia were treated with THC, and out of the group, 13 people experienced significant improvement in their appetite.
CBD can also help those suffering from anorexia feel better after eating and eradicate some of the guilt they often associate with eating food. What’s more, CBD is very valuable for those with mental health issues, which people with anorexia generally suffer from. Anorexia is usually caused by an inner pressure to have and maintain a skinny body image and often causes the sufferer to experience both anorexia and bulimia. A study by Haj-Dahmane and Shen for the Journal of Neuropharmacology looked into the body’s control of serotonin and found that the CB1 receptor partly controls this, having an impact on how you feel. Without serotonin, it can contribute to depression, which in turn can trigger anorexia. A psychiatric disorder, anorexia doesn’t have a set cure. Yet, using CBD to try and tackle the associated causes can make it a lot easier for the sufferer to get better. With a better relationship with food, a better appetite, and more serotonin in the brain to help combat anxiety and depression, it is vital to get the condition under control.
9. CBD Benefits for Cachexia
Cachexia is a condition that occurs when someone experiences a sudden and severe loss of their body weight without having made an effort to do so. Estimates are that in the United States, approximately 9 million patients suffer from Cachexia. Cachexia is also known as “wasting syndrome” and tends to occur in the later stages of a disease. Those with the condition suffer from a lack of appetite and find it difficult to want to eat anything and a loss of muscle, which can leave them feeling very fatigued, depressed, and have a lower quality of life.
Cachexia is often a result of an underlying condition such as AIDS, Cancer, or Multiple Sclerosis. While treatment tends to focus on the individual case, the typical solution is a form of pharmaceutical appetite stimulation to increase the patient’s appetite. A study conducted in 2011 found that CBD increased the appetite in people living with cancer by up to 64 percent. A second study in 2017 backed this up. The 2017 study, conducted at Columbia University, found that medical CBD effectively worked to stimulate the appetite of patients suffering from Cachexia due to AIDS.
The cause of appetite stimulation from CBD resides in the same neurons that produce the feeling of being full and can suppress the body’s appetite, which happens when your brain tells your body you are full. When introduced into the body, cannabinoids “inform” your body that you are hungry, instead of creating the sensation of being full. CBD is also effective at battling some of Cachexia’s other more physical symptoms, such as pain, anxiety, and depression. It can help sufferers feel more relaxed and well in themselves, which leads to a better quality of life.
CBD can also increase physical activity, which is important for those with Cachexia to help rebuild their muscle mass or slow down the decline. At present, there is no specific cure to treat Cachexia. Yet, CBD can help to tackle some of the more debilitating symptoms of the condition – improving appetite, increasing physical activity, reducing levels of nausea, decreasing pain, and giving mental wellbeing a boost.
10. Benefits of CBD in treating Obesity
At present, over 70 million US adults are classified as obese, which is only continuing to increase exponentially. There is no real cure for obesity besides reducing and calorie controlling your diet and regular exercise. Unfortunately, this is very difficult for many, and they suffer from a range of complications that obesity can bring, such as pain, sleeplessness, and mental health issues like depression and anxiety.
In recent years, CBD was trialed to help try and curb obesity, and it has had a good reception thus far. CBD affects the body due to how it works with your natural endocannabinoid systems and the CB1 and CB2 receptors. CB1 receptors are in the brain and nervous system, while CB2 is found within the immune system. For those who are obese, CB1 receptors are more widespread, particularly in the fatty tissue, nodding towards a link between obesity and receptors.
A study conducted recently by the University of Reading found that CBD could reduce food consumption in rats and, therefore, should be able to do so in humans. CBD works to lower lipogenesis, a metabolic process that sees a metabolic intermediate, acetyl-CoA, converted to triglycerides to store fat. CBD can help to limit the excess lipogenesis, reducing the amount of weight that someone puts on. It also promotes fat burn by increasing the metabolic rate of the body. By speeding this process up using CBD, the body can break down some excess body fat.
Ultimately, CBD is powerful for weight loss and tackling obesity because it can inhibit key proteins involved in lipogenesis and creating fat cells. It boosts the cells’ activity to break down body fat and can also aid in decreasing the formation of new ones.
11. Inflammatory Bowel Syndromes and Diseases (IBS and IBD) and CBD
Studies into the use of CBD in patients with IBS and IBD have shown some improvement. More in-depth studies are required examining the use and benefits of CBD products when managing these conditions to draw concrete conclusions as to CBD’s effectiveness.
There are two ways that CBD may be able to alleviate the symptoms of inflammatory bowel syndrome. Approximately 70% of IBS patients experience abdominal pain. CBD may offer a therapeutic value in treating this condition because the CBD receptors are associated with the nerve cells that control visceral pain. Secondly, there are links between IBS and anxiety, and studies have shown that CBD can alleviate anxiety in both humans and animals.
The two types of irritable bowel disease, or IBD, cause inflammation in the digestive system that can result in diarrhea, abdominal pain, and weight loss, among other symptoms. Using CBD has been proven to reduce visceral pain, decrease both gastric and bowel motility and secretions. These effects can have a positive impact on daily life for those suffering from either type of IBD.
A study has shown that CBD oil, when taken in pill form, does have potential benefits in reducing Crohn’s disease symptoms, and another has been demonstrated that CBD may help reduce the inflammation caused by colitis.
CBD products are available in different forms, and some of these are better suited to treating IBS and IBD than others may be. Daily use of CBD pills may help reduce common symptoms, and vaping a CBD based oil may reduce the discomfort caused by a sudden flare-up. If sufferers have trouble swallowing tablets, edible gummy sweets or oils placed under the tongue could offer the same benefit as pills or capsules.
Full-spectrum CBD contains all the natural compounds found in cannabis, including a certain percentage of THC. This form is generally available in oils, vaping oil, edibles, and creams like our 500mg Warming and Cooling CBD Gels. A study conducted in 2018 found that this type of CBD did ease the symptoms and improve some Crohn’s disease sufferers’ quality of life.
12. Benefits of CBD for Migraines
CBD oil can relieve pain and reduce inflammation, meaning that it could help treat migraines. Research over the years has proven that CBD may ease pain, in particular neurological pain, linked with various conditions. CBD affects specific receptors in the brain that play a role in how the body reacts to pain and inflammation. The cannabinoids calm the body’s receptors by reducing the pain signals. Migraines can cause pain, nausea, and inflammation, and CBD products can help to relieve these symptoms.
According to the National Centre for Complementary and Integrative Health, there is evidence to suggest that CBD has modest benefits for various types of chronic pain, including the symptoms of a migraine.
A 2016 study found that the number of migraines patients experienced decreased with the usage of medical marijuana. The primary measure of the study was the number of headaches participants experienced each month. By using medical marijuana, the frequency of migraines reduced from 10.4 to 4.6 per month. Most patients used more than one form of marijuana, and 39.7% reported positive effects. The best results in this study were found by those who inhaled marijuana to stop a migraine in progress. Controlling the amount of the drug consumed was easier through inhalation. The research ended with a statement recommending further studies into the relationship between migraines, marijuana, and marijuana derivatives to understand better the benefits that could be realized.
While CBD’s effects as a treatment for migraines have not been formally researched, there may be some benefit to patients. According to the American Migraine Foundation, CBD may be a viable treatment for some migraine patients who suffer from muscle or joint pain. According to Dr. Silberstein, patients who have a lot of neck pain or soreness may benefit from CBD oil. Using CBD oil may even prevent nausea and vomiting experienced by some migraine sufferers.
13. Benefits of CBD for Nausea and Vomiting
Emerging studies are suggesting that the therapeutic effects of CBD may provide some relief for nausea and vomiting. While most of the research that exists on CBD and nausea is on the benefits that might be felt by people with cancer, CBD based products may also help with nausea caused by motion sickness, depression, and anxiety.
The side effects of chemotherapy mean that nausea and vomiting are common. Research from 2011 suggests that CBD’s interaction with serotonin receptors in the brain may reduce nausea. The same researchers also concluded that THC is more likely to reduce nausea and vomiting than CBD on its own.
Studies using animals that can vomit due to toxic stimulation have shown that cannabinoids, including CBD, have an anti-emetic effect. A small study in 2016 found that people who were suffering from nausea due to chemotherapy found some relief after taking Sativex, a medicine that contains both CBD and THC. The American Cancer Society lists cannabinoids as an appropriate treatment option for nausea caused by chemotherapy when more conventional treatments have not worked. CBD and THC can stimulate the appetite of people with cancer.
Most studies into CBD use in treating nausea and vomiting have involved anticipatory nausea, a severe response that the body can produce while expecting chemotherapy or another sickening situation. This effect can be difficult to treat using a regular anti-sickness medication; however, studies into cannabinoids have been promising in this field.
Most of the benefits provided in this case are likely to come from CBD’s ability to increase anandamide levels, which indirectly activates the CB1 receptors. Activating these receptors can help to inhibit nausea. The exact amount of CBD taken to treat nausea will vary from person to person, and so individuals should always research this amount before starting to consume a CBD based product.
Some sufferers may find increased benefits if CBD is used alongside other herbs known to reduce nausea. Herbs such as ginger, lemon balm, chamomile, and peppermint can be used in conjunction with CBD. Using the two together can speed up the effects, helping sufferers feel better faster.
14. Benefits of CBD for Pain
CBD oil can have a positive effect on chronic pain. Research into this effect is still early, and more detailed studies are required to determine how CBD can help certain conditions. However, a review carried out in 2020 determined that CBD can offer patients an improved quality of life, improved sleep, and effective treatment for intractable pain.
Studies have shown that CBD oil can also help with chronic neuropathy pain. This type of pain is caused by damage to the nerves and is common in multiple sclerosis, herniated discs, and infections such as shingles. While this study yielded positive results, more research is needed to identify the risks, benefits, and ideal doses to use.
An animal study conducted in 2016 investigated the effects of CBD on the pain caused by arthritis. Researchers used a CBD gel on rats who were suffering from arthritis over four days. The study results showed that the rats experienced a significant drop in inflammation and pain but did not cause any side effects.
Multiple sclerosis affects the entire body through the damage it causes to the nerves and brain. One of the most common symptoms of multiple sclerosis is muscle spasms, and these spasms can leave some patients suffering from constant pain. Reports have shown that CBD can benefit patients suffering from this pain as it may reduce the number of muscle spasms felt. The results of the study are modest, and so more in-depth research is needed.
Generalized chronic pain affects a large number of people worldwide. Using the results of multiple studies and trials, researchers have concluded that there is substantial evidence that cannabis can be an effective treatment for adults suffering from chronic pain. Throughout the research, researchers also found that the participants did not build up a tolerance to the treatment, and so would be unlikely to need to increase the dosage over time.
There is scientific evidence to suggest that CBD based products can help individuals manage various types of chronic pain. While CBD products show promise as an effective treatment for pain, more in-depth studies into this treatment’s long-term effects are required.
15. Benefits of CBD for Schizophrenia
The association between psychosis and cannabis has been known for years. Studies as far back as 1982 produced the first evidence to suggest that CBD may have antipsychotic properties that could be useful in treating certain conditions. Surprisingly, the studies showed that the CBD alleviated anxiety while also reducing the psychotic symptoms that THC can induce.
A study of the effects of CBD on schizophrenia was conducted with a patient who suffered many adverse side effects when taking traditional medication. After taking CBD for four weeks, researchers noted a reduction in the psychotic symptoms exhibited using standardized rating methods.
These results were repeated in 2017 in a study conducted by King’s College London. This study found that participants who were treated using CBD experienced fewer psychiatric symptoms than those who received the placebo. The participants’ treating physicians also noted an improvement in their condition when treated with CBD.
The research compared participants who received CBD to both a placebo group and a control group. The study participants were not diagnosed with psychosis but were experiencing symptoms. The patients were asked to complete a memory task that used three different areas of the brain that are associated with psychosis. MRI scans revealed that abnormal brain activity was lower in the CBD group than those who received the placebo. According to a King’s College press statement, these findings suggest that cannabidiol can help brain activity re-adjust to normal levels.
CBD also shows promise in treating the other symptoms and cognitive impairment that can be caused by schizophrenia. Studies using animals found that CBD improved some of the issues experienced, such as social interaction and memory deficits. A significant benefit of CBD compared to traditional antipsychotic medication is that it has fewer side effects. Many antipsychotic medications can reduce the appetite or increase weight gain, and these effects are not experienced with CBD.
While the exact mechanism by which CBD works is still being investigated, it is thought that CBD inhibits an enzyme that counteracts anandamide. This is a natural antidepressant that the brain naturally regulates.
16. Benefits of CBD for Seizure disorders & Epilepsy
Studies have demonstrated that CBD could be an effective treatment for patients with certain types of epilepsy, such as Dravet syndrome and Lennox-Gastaut syndrome. When assessing how effective epilepsy treatments are, researchers tend to focus on whether medicine helps a patient by reducing seizures by 50% or more.
Recent evidential reviews found that CBD is beneficial for some patients with seizure disorders and epilepsy. Approximately one in every eight patients taking CBD reported seizure reductions of 50% or more. A smaller number (about 1 out of every 150 patients) said they became completely seizure-free because of CBD therapy.
The use of medical cannabis to treat epilepsy and other seizure disorders has grown exponentially in recent years. It is effective in treating rare forms of epilepsy that often do not respond to other medications. This response has led to various administrative and governing bodies (including the United States Food and Drug Administration) to approve the use of CBD for the treatment of epilepsy.
Some artisanal CBD oils used to treat epilepsy may also contain small amounts of THC. However, these trace amounts of THC are unlikely to have any psychoactive side effects and are instead used in conjunction with other cannabinoids and compounds found in the cannabis plant as part of an “entourage effect”.
Some doctors prescribe an isolated version of CBD known as Epidiolex to treat seizures. Epidiolex contains approximately 98% pure CBD, although critics of pharmaceutical-grade CBD say that full-spectrum CBD therapy is more effective.
Patients who use CBD products to alleviate or prevent seizures and associated seizure disorder symptoms often do so because cannabis is a completely natural remedy, meaning fewer side effects than medications developed in a laboratory.
Other patients tend to use CBD in conjunction with existing epilepsy medications. Patients who wish to do so are advised to discuss this with their doctor before introducing CBD into their drug regimen or reducing the use of their currently prescribed medication. This is because CBD, though a natural compound, could still interact with some drugs.
Doses of CBD for epilepsy can vary on a patient-by-patient basis. However, it is recommended that children and adults with seizure disorders take between 10-20mg of CBD for every kilogram of body weight per day.
17. Benefits of CBD for Sleep disorders
Research and anecdotal evidence suggest that CBD could help patients with sleep disorders enjoy a better night’s sleep. Insomnia can be caused by a combination of things, including:
• Mental health issues (depression, anxiety, and PTSD, for example)
• Chronic pain
• Excess caffeine use
• Medication that disturbs the natural wake/sleep cycle
• Environmental factors (loud noises or regular disturbances)
Regardless of whether insomnia is caused by external factors or illness, CBD is proven to be an effective means to help achieve restful, good-quality sleep. In 2019, a study found that nearly 80% of patients with anxiety reported a reduction in symptoms, with almost 67% reporting better sleep after a month of taking 25mg of CBD in capsule form.
There is also a growing amount of evidence that CBD can be used to soothe chronic pain. CBD acts as a natural anti-inflammatory, and by helping to reduce pain, it helps patients enjoy better quality sleep.
CBD can also help improve sleep cycles. Research from 2014 found that CBD could improve the symptoms of those suffering from REM sleep behavior disorder. Patients with this disorder are likely to act out their dreams or move in their sleep. This disorder is associated with nightmares and poor-quality sleep, or lack of sleep altogether.
However, CBD might not just be useful as a medicine for treating a lack of sleep. Studies suggest that it could also be helpful as a part of a treatment for excessive sleepiness during the daytime. Grogginess and daytime fatigue are both symptoms of insomnia, and a 2014 study found that CBD could promote wakefulness and mental cognition during the day.
CBD is taken in several ways as a means to improve or promote restful sleep. It is available as:
• Vape concentrates
Vaping generally helps administer CBD into the system faster than any other form. However, some patients find that regularly taking CBD via capsule or edible form as part of a daily routine (an hour before going to bed, for example) helps them enjoy a more restful sleep.
Most patients begin to notice a real difference in sleep quality after a month of regularly taking CBD. Therefore, it is important to remember to consume your regular dosage of CBD every day instead of expecting to experience immediate results.
18. Benefits of CBD for Enhancing sex & libido
It is essential to understand how CBD works within the body and how CBD can positively impact sex and libido. The body contains minute receptors, which are part of what scientists refer to as the endocannabinoid system (or ECS for short). CBD essentially activates these receptors. The indirect effect of CBD on these receptors can affect the body in a variety of ways.
A 2009 article published by the New York Academy of Sciences revealed that the sexual reproductive organs contain ECS receptors. ECS receptors are also present in the brain, which is another erogenous zone. Some researchers have found that CBD use can boost libido by influencing both the brain and the sexual organs.
CBD is known to boost the mood by enhancing the effects of a neurotransmitter known as anandamide. Anandamide is often referred to as the “bliss neurotransmitter” and is closely associated with oxytocin, also known as the “cuddle hormone”. CBD helps increase these natural endorphins and neurotransmitters, leading to a better sexual experience all around.
Further research suggests that CBD could help to improve libido and sexual performance by helping to reduce anxiety. Throughout the world, many people have anxiety about their sexual performance, which can reduce their libido. In theory, if CBD can help alleviate anxiety, the desire for sex should increase.
Anecdotal evidence suggests that CBD could also be useful as a treatment for erectile dysfunction. It is said to help improve sexual performance and ejaculatory function. While the exact science isn’t entirely understood, it is hypothesized that CBD could help to promote blood flow by relaxing the blood vessels. Increased blood flow to the penis helps to relieve erectile dysfunction and promote better longer-lasting sexual function.
Females who struggle with insufficient lubrication could also benefit from the use of CBD. Topical CBD could be used as a lubricant with an anti-inflammatory effect, which in theory could make sexual intercourse more comfortable.
Incorporating CBD products to improve one’s sex life is easy and can be achieved in various ways. Some examples include:
• Taking CBD oil before sexual contact to help boost sensation
• Regularly taking CBD to reduce anxiety associated with sexual performance
• Using CBD massage oil in foreplay
• Applying CBD oil as a lubricant to reduce dryness/enhance pleasure
19. Benefits of CBD for Burnout & Fatigue
Burnout and fatigue can affect your productivity and energy levels, leaving you feeling depressed, anxious, hopeless, and helpless. It is a severe condition that won’t simply resolve itself, and those who begin to experience burnout and fatigue should deal with it before it becomes severe. Thankfully, CBD oil can be of great help to those experiencing symptoms associated with burnout.
Some of the physical manifestations of burnout and fatigue include:
• Changes in sleeping habits
• Changes in appetite/eating habits
• Frequent illnesses due to a low immune system
• Feeling drained and tired all the time
• Experiencing headaches and muscle pain
CBD improves the quality of sleep, regulates appetite, reduces pain/inflammation, and improves productivity. It is the perfect natural remedy for those experiencing the physical symptoms of burnout and fatigue in many respects.
However, not all symptoms of burnout are physical. There’s an emotional side to burning yourself out, and these symptoms can manifest themselves as:
• A loss of all motivation
• A feeling of being trapped, defeated, or helpless
• An increasingly negative outlook
• A pervasive sense of failure or self-doubt
• Detachment, or a feeling of being alone
• A decreased sense of satisfaction or accomplishment
It is important to recognize these and the behavioral symptoms of burnout, which also include:
• Using drugs or alcohol as a crutch
• Taking longer to complete tasks
• Taking out your frustrations on others
• Withdrawing from your responsibilities
Thankfully, several studies have demonstrated that CBD can be used to help improve mental health. It is advantageous in helping to increase productivity and mood while also reducing stress and anxiety. CBD can be used to help quell cravings for foods, alcohol, and other addictive substances (such as nicotine) that many of us can feel tempted to turn to during times of burnout or stress.
However, CBD doesn’t just need to be used to combat these burnout symptoms when they occur. If you actively use CBD daily, you will hopefully find yourself better positioned to deal with work-related stresses. This way, you should find it easier to incorporate a little self-care into your routine to help alleviate burnout and get back to your old self once again.
While the key to avoiding burnout is to keep yourself from burning the candle at both ends, a healthy lifestyle and regular CBD supplements can help you better deal with temporary stresses and better adjust to changes.
10 Studies and Experiments on CBD Health benefits
1) Studies on the benefits of CBD on Anxiety (Generalised Social Anxiety Disorder)
For decades, CBD use was thought to have helped manage and reduce symptoms of anxiety. However, this belief had not been clinically demonstrated until a study was undertaken in 2011.
The UK and Portuguese-based placebo-controlled study managed to demonstrate the efficacy of CBD in helping patients with social phobias concurrent with a diagnosis of Generalised Social Anxiety Disorder. During the study, patients were evaluated for subjective anxiety. They had their brain activity monitored after being administered a bi-daily 600mg dose of isolated CBD within a gelatin capsule. In contrast, other patients in the control group were given a placebo of corn oil.
Ultimately, the study demonstrated that medium-to-large quantities of CBD could help combat the effects of anxiety. This particular experiment proved useful in highlighting the benefits of daily CBD use compared to taking it when anxiety or panic attack symptoms appear, as the patients involved were prescribed the CBD for use on a regular, twice-daily basis.
Since the 2011 study concluded, several other similar experiments worldwide have demonstrated that CBD is a viable treatment for anxiety. It is now one of the most common reasons people use CBD, and as a natural remedy can be considered safer than pharmaceutical prescription medications for anxiety.
2) Studies on CBD Benefits for treating Skin problems
CBD is known to have anti-inflammatory effects. It also appears to help decrease the production of oils that can clog pores while contributing to new cells’ turnover. This effect helps to encourage a youthful appearance and prevents acne and fine lines from developing.
A 2019 article published in the National Library of Medicine found that ointments enriched with CBD could be therapeutic in the treatment of cutaneous scars and skin diseases. The study at the center of the article involved 20 patients, all of whom suffered from atopic dermatitis or psoriasis – two of the world’s most common skin conditions. Each patient administered a CBD-enriched ointment to affected areas of the body twice a day, for three months in total.
Skin evaluations, questionnaires, and photographic data all supported the clinical assessment of the investigators. Results showed that CBD significantly improved skin appearance and reduced the symptoms associated with common skin disorders.
Ultimately, this proved that CBD administration is a safe, non-invasive means to improve the quality of life of patients with inflammatory skin disorders.
It is also worth noting that CBD has also been recommended by some skin experts as part of a daily beauty regime, as the anti-inflammatory and anti-bacterial properties of the compound can help to refresh and revive tired, sallow-looking skin.
3) Studies on CBD benefits for treating Insomnia
A good night’s sleep is essential to help us function throughout the day and is paramount to leading a productive lifestyle. However, a combination of overstimulation, stress, and a poor diet can lead to us experiencing sleeplessness or insomnia.
It has long been known that CBD can help users feel more relaxed, which helps promote a good night’s sleep. As it is a natural remedy, many people prefer to take it as an alternative to potentially harmful pharmaceutical sleep aids – and with good reason, too: it works!
In 2018, the University of New Mexico study into the effectiveness of CBD for the treatment of insomnia found that 95% of a group of 409 users reported positive side effects. During the study, users ingested CBD in a variety of different formats, including a vape pen.
The study concluded that CBD was associated with significant improvements in the sleep patterns of those previously suffering from insomnia and highlighted how CBD’s use as a natural substitute for other substances used to promote sleep, including prescription sleep aids, opioids, and other sedatives.
4) Studies on CBD benefits for Concentration issues
Conditions that affect concentration, such as Attention Deficit Disorder, have historically been treated with prescription medications like Ritalin and Adderall. These medicines can cause a host of unwanted side effects, which is why interest in CBD use for concentration issues is at an all-time high.
A small UK-based pilot study has demonstrated that symptoms of ADD and also ADHD can be combatted with CBD. The study results show that patients reported improved cognition and fewer mood swings compared to when they had no access to medication whatsoever.
CBD is known to affect the levels of a neurotransmitter known as anandamide. It is thought that the effects on this neurotransmitter could be linked to its ability to help alleviate concentration issues.
For those who wish to improve their concentration, CBD is recommended on both an “as needed” basis (when symptoms present themselves) and as part of a daily regimen (taking small doses of CBD twice a day). It can be administered via capsules, as oil, or via a vape pen.
5) Studies on CBD benefits on treating Muscular aches
Given that we know the transdermal application of CBD can effectively reduce inflammation, it should come as no surprise that the compound has proven to be useful in treating muscular aches associated with sporting injuries.
In 2008, a study set out to test the efficacy of cannabinoids in pain management. This peer-reviewed study found that CBD’s analgesic qualities could be used to treat muscular pain effectively because cannabinoids interact with various pain control systems.
In recent years, athletes have increasingly been turning to CBD as a natural remedy for muscular issues caused during competition. It is now a popular form of medicine for professionals and amateurs alike in the worlds of combat sports, gymnastics, football, and more. However, cannabis has long been used as an analgesic, particularly in eastern cultures, where cannabis flowers were routinely prepared for pain relief for centuries.
Other studies have suggested that CBD could be a useful natural alternative to addictive opioids and other pharmaceutical medicines, which tend to cause side effects (such as drowsiness) in addition to their pain-relieving qualities. Experts advise that oil-based tinctures promote real absorption of CBD into the muscles for the best results.
6) Studies on CBD benefits for treating Endometriosis
Endometriosis is a menstrual disorder that causes tissue that resembles the uterus’ lining to develop outside of the uterine cavity. This disorder is an excruciating condition, which can thankfully be alleviated by using CBD, according to a 2017 study.
The endocannabinoid system plays a significant role in menstrual pain. The female reproductive tissues are home to an abundance of endocannabinoid receptors. CBD can help stop the proliferation of endometriosis by acting on these endocannabinoid receptors.
CBD is also known to be an anti-inflammatory agent, which means it can also reduce the pain associated with menstrual cramps. During the 2017 study into the effects of CBD on people with endometriosis, results show that the compound could have positive effects including (but not limited to:
• Decreased cell proliferation (both in vivo and in vitro)
• Decreased pelvic pain intensity
• Decreased assumption of NSAIDs (such as Ibuprofen)
CBD can be ingested in capsule form (in doses of 400mg) or applied as a suppository to relieve menstrual cramps and pain associated with endometriosis.
7) Studies on CBD benefits for Arthritis and joint pain
Arthritis is known to affect nearly one-quarter of the population. Approximately 50% of people with arthritis are limited in their activities because of the illness, and one in four adults with arthritis report chronic severe joint pain.
CBD’s therapeutic potential in treating chronic pain such as arthritis has long been supported by scientific literature. Several studies – including this one from 2016 – have highlighted how transdermal CBD can be used to reduce inflammation and pain-related behaviors. CBD can be taken in capsule, liquid, or vape form to help alleviate pain symptoms associated with arthritis. However, the transdermally applied CBD is considered the quickest-acting form of pain relief. Absorption can be delayed when CBD is ingested (the effects of stomach acids, how recently a patient has eaten, and other factors can all play a role in delaying its efficacy).
Many patients prefer to use CBD as a natural remedy compared to pharmaceutical treatments such as Ibuprofen or Naproxen. Non-steroidal anti-inflammatory drugs can damage the lining of the stomach, resulting in ulcers or other gastrointestinal issues. With CBD, patients don’t need to worry about damaging side effects and instead enjoy natural pain relief.
8) Studies on the benefits of CBD on treating Back stiffness
Several studies have shown that CBD can be useful in treating back stiffness. While most studies tend to focus on cannabinoids in treating chronic pain, a not-so-surprising outcome is that many of these studies also report improvements in muscle stiffness as a secondary effect. These improvements should come as no surprise, given the wealth of evidence that CBD acts as an anti-inflammatory agent and reduces muscle pain.
CBD can be used to treat a stiff back in a variety of ways. While it is useful when ingested, its effects are best noticed when massaged into the affected area. The massage results combined with the transdermal application of CBD in oil form can help to doubly impact the reduction of stiffness in the back muscles.
It’s worth noting that only a small amount of CBD oil is needed to be effective – a small amount (about the size of a blueberry) has been demonstrated to relieve pain when massaged deeply into skin and muscle tissues.
9) Studies on the benefits of CBD for Epilepsy
Proponents of CBD have long been vocal about the positive effects this natural medicine can have on patients with severe forms of epilepsy. Since 2018, many governing bodies (including the United States Food and Drug Administration) have approved CBD oral solutions for the treatment of seizures associated with conditions like Dravet syndrome and Lennox-Gestaut syndrome for patients aged two and over.
A recent UK-based evidence review found that approximately one in every eight epilepsy patients who regularly take CBD could reduce the number of seizures they experience by at least 50%. A small number of these patients (approximately one in 150) would even go on to become completely seizure-free.
Some doctors recommend that CBD can be used successfully as an additional therapy to existing anti-convulsive medicines. It can be taken orally (in capsule or drop form) or ingested using a vape pen. However, at present, CBD is only recommended as a treatment for Lennox-Gestalt and Dravet syndromes.
When choosing to use CBD products to treat seizures, it is vital to let your doctor or epilepsy specialist know, particularly if you intend to take CBD in addition to your existing epilepsy medicines. It would help if you did not replace your existing prescription with CBD or stop taking your medication unless advised to by your doctor.
10) Studies on the benefits of CBD for Temporomandibular disorder (TMJ)
TMJ is the term given to pain around the jaw, temple, and ears. Symptoms include:
• Popping, clicking, or grinding noises when the jaw is moving.
• Recurring headaches around the temples.
• Difficulty opening the mouth fully.
• A feeling of the jaw “locking” into place when opening the mouth.
Clinical trials in the United States have shown that CBD oil can be effective as a means to potentially alleviate pain associated with TMJ, on account of its anti-inflammatory effects.
However, another exciting facet of CBD lies in its anti-anxiety potential. We know that anxiety often causes people to clench their jaw, resulting in pain associated with TMJ. With anti-inflammatory and anti-anxiety properties, use CBD to treat both the root cause and anxiety-based TMJ symptoms.
It is hypothesized that jaw pain can be indirectly caused or contributed to by restlessness and a lack of proper sleep. Therefore, the sleep-inducing qualities of CBD make it a perfect choice for those currently struggling with temporomandibular disorder. It can be applied in drop form, as a topical gel, ingested via capsules, or vaped to achieve an analgesic effect.