CBD has taken the health and wellness industry by storm, and for a good reason. The non-psychoactive compound found within the hemp variety of cannabis is held in high regard for its wealth of therapeutic and pharmacokinetic benefits.

Of course, all anyone ever talks about are the benefits of CBD.

If we may speculate for a moment, this could primarily be because the cannabinoid’s THC counterpart has been under global scrutiny simply because of its psychoactive effects as well as its history of criminalization.

It also suffices to say that there are high hopes for CBD and its possible contribution to natural medicine, enabling the world to finally have a safer alternative to pharmaceuticals and other types of medical treatment.

So when you think about it, the last thing CBD growers, manufacturers, and supporters alike want to do is attach any negative stigmas to the prized cannabinoid. Given the negative stigma surrounding CBD, it may seem like most information glosses over the question does CBD have any side effects? However, just like any other substance, there are potential side effects that come with CBD.


What are the side effects of CBD? Keep reading to find out.

Even with a good understanding of how CBD oil is produced and the antecedence of its cultivation for medical purposes, it is important to consider the side effects of CBD products, and how you could be affected by its use.

Only use CBD products from reputable sources who can verify that they offer pure products, with little or no psychoactive ingredients (if that is your goal).

It is then crucial to begin using CBD cautiously and in lower dosages to measure the physiological impact it has on you. Everyone is different, so you need to leave time to evaluate your reaction and benefits when taking your initial dose.

It would help if you began taking CBD products at home when you are unlikely to be driving in the next few hours.

Beyond that, much depends on the way you choose to take CBD products.

For instance, if you use drops i.e. 5% CBD Oil or higher concentration 10% CBD Oil &  or a spray under your tongue, though there are no known side effects that you should be concerned about, some people report that it results in a dry mouth. As absorption can be rapid, others also feel dizzy and lightheaded to start. If these are issues of concern to you, please consider an alternative way to take CBD i.e. CBD Muscle Relief Warming Gels, or CBD Muscle Relief Cooling Gels

There have been cases in which people using CBD have found that it simply ‘doesn’t agree with them’. They report feeling nausea or irritability, for example. Though the growing popularity of CBD oil to treat an ever-wider range of issues is testimony to the fact, many users have no such concerns!

You also need to be aware of CBD oil’s potential to interfere with existing medications you are using or the potential for it to worsen rather than improve underlying health conditions.

According to one report, CBD can alter other bloodborne medications’ effectiveness in much the same way as grapefruit juice. You will find, for example, some blood thinners and hypertension medications advise against consuming grapefruit, and in those situations, it may be wise to avoid CBD as a health supplement.

Also, CBD and pregnancy and breastfeeding are complex issues. Using highly concentrated CBD products when prescribed other relaxants can also produce an extreme result.

A deeper look into potential side effects of CBD

Generally speaking, cannabidiol (CBD) is considered a safe substance when ingested or used topically. It’s also important to reiterate that CBD is a non-psychoactive cannabinoid, so it won’t get you high, which means that those who can’t use THC or dislike the high it gives don’t have to worry about that with CBD.

So—does CBD have any side effects? The honest answer is yes. These are the most common:

  • Drowsiness
  • Changes in mood
  • Gastrointestinal issues
  • Low blood pressure
  • Nausea
  • Possible interactions with other medications

These side effects are indeed very rare in their occurrence, as you’ve probably heard or read before, but they do exist.

Let’s take a closer look at these side effects:


Drowsiness is a common side effect of CBD. It’s also a benefit to those taking CBD to help them sleep. According to a study published in the Medical Journal of Pain, the “sleep response” is triggered when CBD binds to the 5-HTa serotonin receptors.

Essentially, when CBD binds with these receptors, it blocks them from binding with any antagonists that would otherwise keep you awake by activating your sensory neurons.

Changes in Mood

Another common reason people turn to CBD is to quell their anxiety or lift their depression. As a side effect, CBD has the potential to affect an individual’s mood, regardless of their reason for consuming it.

Once again, this has everything to do with the way CBD binds with the C1 receptors in the brain. While the research in this area is still ongoing, there is promising evidence that CBD acts as a reuptake inhibitor and an allosteric modulator.

In other words, it mitigates the neuron transmissions and responses within the brain, which in turn affects the levels of chemical neurons such as serotonin, dopamine, anandamide, and so on—ultimately affecting our mood. These same neural responses can also affect an individual’s appetite.

Of course, there’s always the possibility that CBD can have an exacerbating effect on anxiety levels, but these instances only happen when an individual has taken the wrong dosage or even the wrong strain.

Gastrointestinal Issues

Some individuals have experienced gastrointestinal issues, namely diarrhea, after taking CBD. Of course, this is mainly due to taking the wrong dosage, as in too much. It also depends on the individual and their medical history.

Gastrointestinal issues are scarce as CBD is generally well-tolerated among most individuals. However, everyone’s physiological makeup is slightly different, so it’s essential to pay attention to dosage during the adjustment period.

Low Blood Pressure

One of the more physical potential side effects of CBD is low blood pressure, as the substance tends to relax the blood vessels. Lowering blood pressure is usually a favorable side effect for individuals with chronic anxiety and high blood pressure.

However, taking CBD when you’re already on blood pressure medication can cause your blood pressure to sink below normal levels, which can have some adverse side effects, including dizziness.


While some individuals take CBD to combat nausea, the substance causes nausea in others. These side effects typically occur because some individuals are sensitive and don’t digest CBD very well or already have digestion issues, to begin with.

Another factor to consider is that CBD is a mostly under-regulated substance, so that a poor-quality product could be the culprit.

Interactions with Other Medications

Arguably the most critical side effect to understand before taking CBD is its potential to interact with other medications. Clinical research has shown that once the Cytochrome P450 enzyme metabolizes CBD in the liver, it becomes a “competitive inhibitor.”

In other words, it has the potential to slow down the metabolization rate of the liver. When this happens, any toxins, i.e., pharmaceuticals, remain in the body longer, which can cause individuals to have adverse reactions.

It’s important to note that CBD isn’t unique in this instance. Many medications and natural substances can have this effect on the liver. While no one has ever died or been hospitalized from taking CBD, it’s still critical that you speak with your physician before adding CBD to your daily regimen—especially if you’re taking any other medications.

Avoiding the Potential Side Effects of CBD

Now, rather than asking, what are the side effects of CBD, you’ll need to ask how can I avoid any potential side effects of CBD?

The answer is quite simple.

First and foremost, you should only buy CBD products from reputable brands. How do you know a brand is reputable? They’ll only use organic and safe ingredients in their products. They’ll also be transparent by including a Certificate of Analysis (COA) on their label.

The COA lets you know exactly what’s in the product and ensures that your CBD only contains 0.03% THC or less. With the COA, you’ll be able to trace the CBD back to the farm it grew on.

Lastly, stick to a smaller dose and give your body time to adjust before increasing the amount. Since CBD is an underregulated substance, dosing can be tricky, but the manufacturer you purchase from should have some dosage guidelines on their site.

Have more questions about CBD or looking for the right product for yourself? Reach out to us today to have all your questions answered.

If you have any questions or concerns about the way CBD products may interact with your other medications or the potential for CBD to adversely impact a health issue, it is vital to seek your medical practitioner’s advice.

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